We observed a significant decrease in the protein levels of COX-2, PPAR-γ, and NFκΒ/P65 in HCT116 (Human colorectal carcinoma cell line) and HT29 (Human colorectal adenocarcinoma cell line) cells after 24 h of treatment with ethyl acetate and methanolic extracts of A. rosea, suggesting that these extracts could be of potential use for the isolation of novel metabolites with anti-inflammatory and anticancer properties. The gene discussed is PPARG; the disease is colorectal carcinoma.