Conversely, reduced glycemia (hypoglycemia) was caused by hepatocyte-specific loss of Nrf1 or Nrf1:Nrf2, but not Nrf2, in mice (fed with a mild stressful fat-fructose-cholesterol diet for one to three weeks), but this phenotype did not occur in the leptin-deficient mouse model with obesity and diabetes (leptinob/ob:Nrf1flox/flox) 356. This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.