This is much likely to further dictate the morphostasis of distinct topogenetic phenotypes with healthy physiological functions, because the loss of its function results in severe endogenous oxidative stress, as accompanied by disruption of cellular lipid, glucose and protein homeostasis and organ integrity, leading to cancer development and malignance, even though Nrf2 is aberrantly accumulated in such Nrf1α-deficient cells (Figure 3B) 115. This evidence concerns the gene NFE2L2 and cancer.