NFE2L2 and hepatocellular carcinoma: This notion is solidly based on the gene-targeting experimental evidence revealing those unique pathophysiological phenotypes of Nrf1 but not Nrf2, as evinced in those distinct tissue-specific knockout mice (see section "Unique pathophysiological phenotypes of Nrf1 that are distinctive from Nrf2"), as well by their specific knockout cell lines from the human hepatoma (Figure 13A).