Thereby, it is inferable from the aforementioned findings that Nrf1 and Nrf2 are differentially and integrally required for the multifaceted crosstalk between redox responsive signaling and metabolic pathways to coordinately control a vast variety of the relevant signaling molecules and metabolic enzymes involved in cancer metabolism, aiming to sustaining robust redox homeostasis and metabolism homeostasis (metabostasis, including glucose, lipid, cholesterol and protein homeostasis. This evidence concerns the gene NRF1 and cancer.