Liver-specific KO of Nrf1 (to delete the fourth exon encoding aa 296-741, i.e., LCR-F1/Nrf1β) in the adult mouse resulted in a typically pathologic phenotype that resembles NASH and hepatic neoplasia, including hepatocellular adenomas and carcinomas, which spontaneously developed as early as four months after birth 261. This evidence concerns the gene NRF1 and metabolic dysfunction-associated steatohepatitis.