NRF1 and osteoporosis: KO of all isoforms of Nrf1’s transcripts specifically in themyeloid lineage in Nfe2l1(M)-KO mice (yielded by crossing mice bearing the floxed Nfe2l1 allele with mice expressing LysM-Cre) caused the increased activity of osteoclasts, decreased bone mass and worsening of osteoporosis induced by ovariectomy and aging 395.