NFE2L2 and osteosarcoma: By analysis of the chromatin immunoprecipitation (ChIP)-sequencing combined with RNA-sequencing data, 31 differential expression genes (DEGs) were identified as co-targets of Nrf1, Nrf2 and Nrf3 (i.e., doxycycline-inducible FLAG-tagged Nrf1ΔN1-121, Nrf2 and Nrf3ΔN1-173 in the human osteosarcoma U2OS cell lines) 117.