The above-described finding is consistent with our previously reported results, revealing the opposing effects of Nrf1 and Nrf2 on PTEN (phosphatase and tensin homologue) 265, which negatively regulate the intracellular levels of phosphatidylinositol-3,4,5-trisphosphate (PI3) and functions as an upstream tumor suppressor by negatively regulating PI3K-AKT-mTOR signaling (Figure 13B). This evidence concerns the gene NRF1 and neoplasm.