Conversely, greater increases in the two known NASH-drivers IHH(Indian hedgehog) and tnfrsf12a (TNF receptor superfamily member 12A) were caused by combined Nrf1:Nrf2 deficiency, and also accompanied by increased expression of 4-hydroxynonenal (4HNE)-conjugated proteins, as well as of TAZ (taffazin) and YAP1 (yes-associated protein 1), which drive IHH expression and steatohepatitis 351, 352. This evidence concerns the gene NRF1 and metabolic dysfunction-associated steatohepatitis.