The hepatocyte-specific KO of Nrf1 (to delete a fragment spanning exons 4 and 5 of this gene encoding its DNA-binding domain in the homozygous mice obtained by crossbreeding C57BL/6N-A/a chimeric males with C57BL/6J females) led to the substantial aggravation of cholesterol-led pathological phenotype in the liver that resembles human hepatosteatosis and NASH 347. Here, NRF1 is linked to metabolic dysfunction-associated steatohepatitis.