The GAMM model was used to illustrate the trajectories of PLT counts over time for patients in the 28-day survival and mortality groups, adjusting for confounding factors such as age, sex, stroke, WBC, Lac, cTnI, FIB, ABX < 1 h, 24-h fluid balance, SOFA score, infection site, CRP, MAP, CHD, DM, CHF, MV, and CRRT (Figure 4). This evidence concerns the gene TNNI3 and infection.