Furthermore, mtROS produced by the overexpression of ubiquinol cytochrome c reductase binding protein (UQCRB) facilitated autophagic flux by lysosomal biogenesis through activation of the transient receptor potential cation channel, mucolipin subfamily 1 (TRPML1) Ca2+ channels and TFEB nuclear translocation and protects against HCT116 colorectal cancer [168]. Here, UQCRB is linked to colorectal cancer.