Furthermore, Smac mimetic (BV6)/glucocorticoid (dexamethasone)‐induced necroptosis involves BAK activation by RIP3, which was followed by MLKL‐mediated ROS generation, that ultimately resulted in mitochondrial dysfunction and the death of acute myeloid leukemia cells (Tanoue and Jurkat cells) and colon carcinoma cells (MV4‐11 and HT‐29 cells), which was confirmed by a significantly decrease in necroptosis after Bak knockdown [100]. The gene discussed is BAK1; the disease is colon carcinoma.