Phosphatidylinositol 3‐kinase gamma (PI3Kγ) inhibitor can sensitize the anti‐programmed death‐1/programmed death ligand‐1 (anti‐PD‐1/PD‐L1) response in ovarian cancer by modulating the PI3Kγ‐AKT‐NF‐κB pathway to remodel tumor immune microenvironment as an activated status, along with downregulating the expression of PD‐L1. Here, CD274 is linked to neoplasm.