ANPEP and anaphylaxis: In a low-dose model of passive systemic anaphylaxis in mice, the antigen-dependent decrease in body temperature—reflecting the severity of the anaphylactic reaction—was significantly exacerbated by the CD13 inhibitor bestatin (−5.9 ± 0.6 °C) and by CD13 deficiency (−8.8 ± 0.6 °C), compared to controls (−1.2 ± 1.97 °C).33