LYP, the dimethylaminoethyl ester of bestatin, demonstrated greater inhibition of ovarian carcinoma cell growth and more effective suppression of APN activity compared to bestatin itself.128 LYP inhibited the growth of ES-2 cells, which express high levels of APN/CD13, significantly more than that of SKOV-3 cells, which lack APN/CD13 expression. The gene discussed is ANPEP; the disease is ovarian carcinoma.