Previous investigations revealed the beneficial effects of bromelain in conditions linked with inflammation, such as rheumatoid arthritis, inflammatory bowel disease, severe coronavirus 2 acute respiratory syndrome (SARS‐CoV‐2), skin wounds and burns [21, 22, 55, 56] Since bromelain shows anti‐inflammatory properties by regulating bradykinin blood levels, inhibiting pro‐inflammatory factors (like prostaglandin E2 and thromboxane A2) and increasing anti‐inflammatory factors (including prostaglandin (PG) I2 and PGE1) [21, 22, 56]. Here, KNG1 is linked to rheumatoid arthritis.