In patient cells, a hallmark of HD pathology is the formation of mutated HTT exon 1 (HTTex1) fragments,[2, 3] which are highly aggregation‐prone, interfere with the cellular pathways, and may contribute to disease progression.[4] Given the pathological significance of HTTex1 generation, misfolding, and aggregation, HTTex1‐binding antibodies have emerged as indispensable tools for both research and potential therapeutic approaches.[5, 6] DiFiglia et al. Here, HTT is linked to Huntington disease.