Given the established role of PI3K/AKT in ESCC and its potential crosstalk with the ZNF468–AURKA axis, this study elucidates how the ZNF468–AURKA axis collaborates with PI3K/AKT signalling to drive tumorigenesis and EMT in ESCC, revealing a novel regulatory mechanism and potential therapeutic target. This evidence concerns the gene AURKA and esophageal squamous cell carcinoma.