EGF and neoplasm: While the gene silencing efficacy of SmiRNP‐EGF‐H5E (IC50 = 504 nM) in HCT116 cells is still not comparable to that of lipofectamine transfection of siRNA,[19] the SmiRNP delivery system that we reported here could target a non‐liver xenografted tumor and is not toxic, based on our mouse model studies.