Our study delves into the regulatory landscape of circCDYL and its host gene, CDYL, a gene coding for the Chromodomain Y Like protein, a pivotal Crotonyl‐CoA Hydratase (CoAP) involved in spermatogenesis [7], which has been reported to be implicated in carcinogenesis, chemoresistance, and tumor invasiveness [5]. The gene discussed is CDYL; the disease is neoplasm.