For example, CD44 (Chen et al., 2018), ARIH2 (Geng et al., 2022), CSDE1 (also known as UNR) (Wurth et al., 2016), CYB5B (Murphy et al., 2010), SF3B1 (Alors-Perez et al., 2021), and RCN2 (Ding et al., 2017; Ning et al., 2023), which have been reported to be overexpressed in cancer, showed an increased proportion of shorter 3′-UTRs, primarily as a result of alternative cleavage and polyadenylation (APA) (Fig. 3G–J). Here, RCN2 is linked to cancer.