This finding aligns with the observed upregulation of IFITM3 in platelets from patients infected with the Delta variant18 and platelets and MKs of COVID-19 patients.10,11 In contrast, other variants exhibited distinct transcriptomic profiles, with WA1 and Omicron showing unique patterns of gene regulation that reflect their differing impacts on cellular processes. Here, IFITM3 is linked to COVID-19.