However, many investigations utilizing immunostaining methods have demonstrated that various cell types, such as astrocytes, microglia, neurons, and ECs, in the AD brain exhibit elevated concentrations of senescence‐linked proteins, such as cell cycle inhibitors p16, p53, and p21 [205, 207, 213, 218, 219, 220, 221, 222, 223]. The gene discussed is TP53; the disease is Alzheimer disease.