The characterization of the plasma proteome demonstrating significant differential expression during sepsis (Fig. 2E) principally comprises three major types of proteins: (1) Proteases involved in the complement and coagulation cascades, including serpina1e, A2m, AT III, C1ra, CFD, C8a, C8b, F13b, Klkb1, Masp1, and Mbl2; (2) Extracellular proteins participating in focal adhesion processes, such as Actn1, Col1α1, Col1α2, EGFR, Flnc, Tga8, Lamc1, Thbs1, and Flt4; and (3) Proteins associated with phagosome activity, including Actn1, Col1α1, Col1α2, C8a, C8b, and Lamc1. The gene discussed is A2M; the disease is Sepsis.