For example, cg10735632 is annotated to the TSS1500 region of the C2orf40 gene, which may influence cancer development by downregulating the expression levels of this gene, as reduced expression of C2orf40 has been implicated in the progression of prostate cancer, breast cancer, lung cancer, and colorectal cancer, where it is associated with tumorigenesis and metastasis [56]. This evidence concerns the gene ECRG4 and prostate cancer.