To investigate the role of the HSD10 in AD-related pathogenesis, stably-expressing monoclonal cell lines of human embryonic kidney HEK293 cells were created, overexpressing either HSD10 (referred to as HSD10 cells; Fig. 2A, Supplemental Figure S1-S2) or APPSwe/Ind protein (amyloid-β precursor protein isoform 695 harbouring Swedish and Indiana mutations; referred to as APPSwe/Ind cells; Fig. 3A, Supplemental Figures S4-S5). The gene discussed is FSIP1; the disease is Alzheimer disease.