CLDN1 and stroke disorder: These findings complement TZP’s ability to reduce stroke-induced BBB permeability (Ki: 1.447 ± 0.103 μL/g/min in MCAO + TZP vs. 2.582 ± 0.156 μL/g/min in MCAO, P < 0.005, Fig. 2A) and enhance CNS penetration (Kp, brain: 0.12–0.14, Fig. 2B) through C/EBP-α-mediated restoration of Claudin-1.