Although no studies have been conducted on the involvement of FOXP1, FOSL2, and BACH2 in keloids, bioinformatics analysis of fibroblast transcriptome in systemic sclerosis (SSc) has revealed that upstream TFs (FOSL2 and FOXP1) drive myofibroblast differentiation and regulate collagen production; BACH2 has also been reported to be involved in the skin fibroblast photoaging process [74, 75]. The gene discussed is FOSL2; the disease is keloid.