The results of this study thus identify a clear role for UPP1 in neutrophil driven metastatic niche priming, providing exciting opportunities to investigate the clinical applications of these observations, including understanding whether circulating uracil could be used as a biomarker to detect metastatic disease, and testing the ability of UPP1 inhibitors to decrease the risk of distant metastasis, and/or improve responses to cancer immunotherapy. The gene discussed is UPP1; the disease is metastatic neoplasm.