For colorectal cancer, villinCreER; KrasG12D/+; Trp53fl/fl; R26N1icd/+ (KPN) mice were used, a model in which NOTCH1 activation is induced specifically in the intestinal epithelium to generate highly metastatic KrasG12D-driven cancer; representative of the serrated colorectal cancer subtype (Jackstadt et al, 2019). This evidence concerns the gene NOTCH1 and cancer.