Using another tumor model, MC38, CD8+ TILs from mice receiving T cells initially activated in 0.03 mM Met for 30 min revealed increased Tex (PD-1+Tim-3+) and Texterm (Ly108−Tim-3+) as compared to T cells initially activated in 0.01 Met (Extended Data Fig. 2o). Here, PDCD1 is linked to neoplasm.