RAG1 and neoplasm: We then transferred these cells into mice bearing B16 or MC38 tumors expressing ovalbumin (B16-OVA, MC38-OVA) 24 h after activation (Fig. 1d), and observed defective tumor control in T cells activated in 0.03 mM Met compared to 0.1 mM Met across all timepoints, with the earliest being 30 min (Rag1−/− mice (Fig. 1e–g); WT mice (Extended Data Fig. 1b,c)).