DNMT1 and obesity due to melanocortin 4 receptor deficiency: To explore whether Dnmt1/3a deletion rescued the obesity phenotype in HFD-fed EP3F/FLysMCre mice, Dnmt1/3a-floxed mice were crossed with EP3F/FLysMCre mice to generate EP3F/FDnmt(1,3a)2F/2FLysMCre mice (Appendix Fig. S10A–C).