INS and Hypoglycemia: This aligns with findings in PcAS-infected adrenalectomized mice, in which severe hypoglycemia also develops without significant changes in insulin, and in which treatment with clonidine, a well-known alpha-2 adrenergic agonist that inhibits insulin secretion from pancreatic beta cells, failed to prevent severe hypoglycemia (Vandermosten et al, 2018a).