IL17A and psoriasis: In this model, daily IMQ application on depilated mouse skin for 4 to 7 days reproduces macroscopic (thick and scaly skin) and microscopic (acanthosis, hyperkeratosis, parakeratosis) features of psoriasis, together with the activation of the Th17 signaling pathways (IL-23/IL-17 axis) and the subsequent recruitment of immune cells (e.g. T cells, neutrophils, dendritic cells)13,14.