In addition, the Log2 ratios of IVL, KRT10 or KLK5 expression after LT-IMQ treatment were all closer to the corresponding Log2 ratios of human patients with psoriasis, suggesting that disruption of epidermal differentiation is a hallmark of chronic inflammation, which is elegantly translated in the LT-IMQ treatment model. The gene discussed is KLK5; the disease is psoriasis.