We focused on the expression of several psoriasis-related cytokines (IL-17A, IL-20, IL-23, IL-1α, IL-1β), chemokines (CXCL3) and AMPs (S100A9, BD3) but also on epidermal markers (KRT10, KRT6, IVL, KLK5), dermal markers (COL1A1, COL3A1) and molecules implicated in vasodilation (NGF, iNOS, TAC1), all known to be differentially expressed in human lesional psoriatic skin compared to healthy skin. The gene discussed is KLK5; the disease is psoriasis.