POLE and colorectal cancer: The associations between MSI-H and POLE mutant forms of colorectal cancer and B2M and PTEN mutations were only observed in MSKCC, with MSI-H and POLE mediated hypermutation occurring in 8% (5/62) vs. 1% (3/246) (p = 0.002), and mutation rates of 5% (8/62) vs. 0% (0/246) (q < 0.001) in B2M and 13% (8/62) vs. 2% (6/246) (q = 0.004) in PTEN for encapsulated versus non-encapsulated, respectively.