B2M and neoplasm: In comparison, only one MSI-H tumour was identified in the New EPOC in a non-encapsulated patient (p = 0.54, Supplementary Table 4 and Supplementary Fig. 4), and for both B2M and PTEN only two pathogenic mutations were present, one in each growth pattern phenotype (both q = 0.80, Supplementary Table 4 and Supplementary Fig. 3).