In an initial study investigating KDM2A’s role in spermatogenesis, Xiong et al.60 generated germ cell-specific Stra8-Cre driven deletion of Kdm2a exon 6 and observed partial abnormalities in seminiferous tubules and oligospermia, concluding that KDM2A is nonessential for spermatogenesis. Here, KDM2A is linked to oligospermia.