Based on these findings, we investigated the effects of excretory-secretory (ES-Ag) and somatic antigens (S-Ag), as well as their combination (ES/S-Ag), on the expression of the master regulators FOXP3 and RORɣt, and the balance between them, which is a marker of inflammatory status in autoimmune diseases like IBD. Here, RENBP is linked to inflammatory bowel disease.