Mechanistic experiments including loss-of-function (LOF) and gain-of-function (GOF) such as knock-down using shRNA or siRNA and overexpression of JUNB in EAC cell lines and organoids should clarify the pathophysiological mechanisms of JUNs, as well as their impact on (radio-) chemoresistance and patient survival in esophageal adenocarcinoma. This evidence concerns the gene JUNB and esophageal adenocarcinoma.