In addition to schizophrenia, large-scale genetic studies have also implicated rare loss-of-function variants in GRIN2A to seizure and neurodevelopmental disorders, and it has been proposed that the illness that results from a rare loss-of-function variants in GRIN2A (i.e., schizophrenia vs. epilepsy vs. intellectual disability) depends on the specific loss-of-function variant [39]. Here, GRIN2A is linked to neurodevelopmental disorder.