As a first step towards characterizing the schizophrenia clinical presentation that may be most likely to improve with activation of GRIN2A, whole-exome sequencing data from approximately 30,000 individuals in a large United States health system were mined to identify and clinically characterize carriers of rare LoF variants in GRIN2A (i.e., using the same definitions of rare and of LoF used in the study that implicated GRIN2A rare LoF variants in schizophrenia). This evidence concerns the gene GRIN2A and schizophrenia.