Notably, methionine aminopeptidase 2 (METAP2), primarily responsible for regulatory functions related to translational initiation and cellular growth [31], has been a tentative drug target for the treatment of cancer [32] was prominently reduced in FLIX5-treated samples (fold change FLIX5/DMSO = 0.49, p value = 0.03, Supplementary Fig. 5B). Here, METAP2 is linked to cancer.