PPIF and neoplasm: The CypD KO cells led to a 3-fold increase in metastatic foci on the lung surfaces (Supplementary Fig. 1a), and exhibited a 5-fold increase in lung-infiltrating metastases than control cells (Fig. 1f); however, CypD KO did not affect cell proliferation in vitro or tumor growth in vivo (Supplementary Fig. 1b, c).