The genes regulated by the lead SNPs of the phenotype Pulpitis had described functions in autophagy (VMP1), cilia function (INVS and TUBD1), nerve function (NOVA1), dentin formation, tooth pain transmission (INVS)31, and pulpitis (LIF)17, whereas PDE4B is related to sweet taste signalling and associated with the expression of leptin receptor involved in regulating the balance between food intake and energy consumption32. This evidence concerns the gene PDE4B and pulpitis.