In our gene ontology analyses of the protein-coding gene families, the results were dominated by MHC Class II -related pathways:Pulpal and apical diseases and Pulpitis were associated with genetic variants near HLA-DRB1, whereas Necrosis of pulp or apical periodontitis associated with variation near HLA-DQA1. The gene discussed is HLA-DRB1; the disease is pulpitis.