TPCN2 and periapical periodontitis: Among 18 SNPs analysed (Supplementary Table 2), one presented a significant association with the phenotype Pulpitis (rs12800372, p = 0.002, near genes TPCN2 / LOC338694), whereas no significant associations with Pulpal and apical diseases or Necrosis of pulp or apical periodontitis were observed.