EPO and acquired polycythemia vera: <h4>Aims</h4>The aim of this research is to diagnose polycythaemia vera (PV) disease using different machine learning (ML) algorithms with complete blood count (CBC) parameters before further investigations such as Janus kinase 2 (<i>JAK2</i>), erythropoietin (EPO) and bone marrow biopsy (BMB).<h4>Methods</h4>The study included 1484 patients who presented to the adult haematology clinic with elevated haemoglobin.