JAK2 and acquired polycythemia vera: As a result of the t-test, there was a highly significant difference between the WBC, PLT, HGB, HCT, EPO, <i>JAK2</i> and bone marrow density results of PV and other groups (p<0.001).<h4>Conclusion</h4>ML algorithms can diagnose PV with CBC parameters with high accuracy, thus emphasising the potential to reduce the dependence on costly diagnostic methods such as <i>JAK2</i>, EPO and BMB.