LINC00969 collaborated with EZH2 to transcriptionally modulate the levels of H3K27me3 in the NLRP3 promoter region, thereby epigenetically suppressing NLRP3 expression, conferring an anti-pyroptotic phenotype, and enhancing TKI resistance in lung cancer (Figure 3(h)) [46]. Here, NLRP3 is linked to lung carcinoma.