TNF and diabetes mellitus: They found that transcriptomic analysis indicated Syk/BLNK/NF-κB signaling was significantly up-regulated in post transplantation diabetes mellitus group, and pathological staining, immumohistochemical staining, immunofluorescent staining, western blot verified Syk/BLNK/NF-κB and TNF-α/IL-1β were all significantly increased (p < 0.05 or p < 0.01), demonstrating the mechanism of TAC-induced pancreatic injury via Syk/BLNK/NF-κB signaling.