Notably, integrin β3, EMT, and basal molecular phenotypes have been reported to drive metastatic progression.10,39–45 We then extended this concept to create an 18-gene signature (STRESS) to identify patient tumors capable of STAT3-mediated adaptation to stress/inflammation, as defined by STAT3-pY705 binding to differentially accessible enhancers regulating target genes, which are also highly correlated with poor survival in the TCGA pancreatic cancer dataset. The gene discussed is STAT3; the disease is pancreatic neoplasm.