Notably, integrin β3, EMT, and basal molecular phenotypes have been reported to drive metastatic progression.10,39–45 We then extended this concept to create an 18-gene signature (STRESS) to identify patient tumors capable of STAT3-mediated adaptation to stress/inflammation, as defined by STAT3-pY705 binding to differentially accessible enhancers regulating target genes, which are also highly correlated with poor survival in the TCGA pancreatic cancer dataset. Here, STAT3 is linked to familial pancreatic carcinoma.