STAT3 and pancreatic adenocarcinoma: In contrast, the STRESS signature had a strong positive correlation to the cell line-derived β3-inducible signature in patients in the TCGA-PAAD cohort (Figure S7B), despite having no overlap in genes (Figure S7C; Table S3), reinforcing the idea that a cell can activate specific gene expression programs only if they possess the requisite chromatin-accessible states at specific enhancers to which STAT3 binds.