The ability to induce β3 is necessary for a cell to initiate tumors at primary or metastatic sites, as evidenced by our in vivo data and supported by informatics analysis showing that non-inducible PDAC cell lines have a lower metastatic potential and ITGB3-High PDAC tumor cells in patients associated with EMT and the basal molecular phenotypes. The gene discussed is ITGB3; the disease is neoplasm.