ITGB3 and cancer: Importantly, like STAT3, ITGB3 promotes stress tolerance, tumor initiation, and cancer progression.9,10,14–16 Considering the strong correlation between ITGB3 and poor RFS in patients with PDAC, we characterized the mechanism by which STAT3 regulates ITGB3 expression and investigated the role of this STAT3/integrin axis in PDAC progression.