Interestingly, integrin β3, the ITGB3 gene product, and its functional heterodimer integrin αvβ3 have also been reported to drive tumor initiation, drug resistance, and metastasis, similarly to STAT3,9–11 suggesting an important JAK/STAT3/integrin β3 signaling axis in PDAC. This evidence concerns the gene STAT3 and neoplasm.