This study assessed CSPG4 expression in benign nevi (BN), dysplastic nevi (DN), and superficial spreading melanomas (SSM), comparing it with PRAME (PReferentially expressed Antigen in MElanoma) and evaluating the cell division cycle 7‐related protein kinase (CDC7) and the proliferation marker Ki67. This evidence concerns the gene WEE1 and superficial spreading melanoma.