Consistent with the findings in murine central nervous system tissue (19), a reduction in FUSint6&7-RNA was observed in human ALS-FUS cell models—FUSΔNLS SH-SY5Y (human neuroblastoma) lines generated by CRISPR-Cas9 editing to endogenously express FUS lacking NLS (Fig. 1, B to D) (17). Here, FUS is linked to amyotrophic lateral sclerosis.