The biological activities of Phe-a and Pph-a have been studied; a human promyelocytic leukemia cell line, HL-60, is induced to undergo apoptosis upon treatment with Phe-a or Pph-a and light, and Phe-a and Pph-a exhibit antiadipogenic activity [35,40]. The gene discussed is ENO1; the disease is acute promyelocytic leukemia.