In this module, a positive regulation of NF-kappaB transcription factor activity and I-kappaB kinase (IKK)/NF-kappaB signaling was characterized by a submodule involving MAVS, NOD1, RIPK1, TAB1, and TIRAP from TNBC cancers, ALPK1, IRAK4, MAP3K7, RIPK1, TAB1, TICAM2 from HER2-enriched cancers, and ALPK1, MAP3K7, and TIFA from luminal B cancers. This evidence concerns the gene ALPK1 and cancer.