VWF and deep vein thrombosis: Moreover, experimental evidence from in vitro and animal studies has shown that NETs contribute significantly to the formation of deep vein thrombosis (DVT) and the development of thrombus by activating FXII, inhibiting plasma tissue factor pathway inhibitor (TFPI), stimulating platelet activation, and capturing von Willebrand factor (VWF) [16,17,18,19].