Genes associated with B cell trafficking (CXCL3, CXCR5, CCR6, and CCL20) and IFN-γ downstream chemokines (CXCL9, CXCL10) were upregulated, while pro-inflammatory genes (IL-2, IL-6, IL-8) were not, indicating tumor microenvironment remodeling [241,242]. This evidence concerns the gene IL6 and neoplasm.