SOD1 and amyotrophic lateral sclerosis: There was also significant overlap between ALS-increased DEGs and orthologues of microglia-expressed genes identified from SOD1-G93A mouse spinal cords, including genes up-regulated in disease-associated microglia from this model (Figure 5F) [85] and genes having increased expression in SOD1-G93A microglia (endstage disease) as compared to wild type mice (Figure 5H) [86].