ALS-increased DEGs linked to ALS-increased proteins included GPNMB, IQGAP2 and APOE (Figure S24E), whereas ALS-decreased DEGs associated with ALS-decreased proteins included CKMT2, EDIL3 and LDLRAP1 (Figure S24F). The gene discussed is CKMT2; the disease is amyotrophic lateral sclerosis.