ALS-increased DEGs were also enriched for genes related to phagosome, vesicle, plasma membrane, TYROBP microglia network, CD3/TCR zeta chain phosphorylation, demyelinating disease, macrophage activation and the nonsteroidal anti-inflammatory drug lumiracoxib (p < 0.05, Additional File 1). This evidence concerns the gene TYROBP and demyelinating disease.