Several of the ALS-increased DEGs linked to SOD1-G93A microglia in these ways (Figure 5G,I) were also part of the above-mentioned CDAM/HuMicA signatures linked to neurogenerative conditions in humans (Figure 5C,E) (e.g., GPNMB, APOC1, APOE, CAPG, LYZ). This evidence concerns the gene GPNMB and amyotrophic lateral sclerosis.