MAP3K1 and acute myeloid leukemia: In terms of the p-value (padj), the most deregulated gene is BAALC (Brain And Acute Leukemia, Cytoplasmic) [18], a gene responsible for acute myeloid leukemia (AML), and known to potentiate the oncogenic ERK pathway through interaction with MEKK1 and KLF4 [19].