Classical Homocystinuria (HCU) and Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) were more prevalent among Qataris, while Biotinidase deficiency, Galactose-1-Phosphate Uridylyltransferase (GALT) Deficiency, Phenylketonuria (PKU), and Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD) were more frequently reported in non-Qataris. The gene discussed is GALT; the disease is biotinidase deficiency.