In this study, we investigated the expression levels of m6A writers (METTL3 and METTL14), readers (YTHDC1, YTHDC2, YTHDF1, YTHDF2 and YTHDF3) and erasers (FTO and ALKBH5), and overall RNA m6A levels in keratinocytes derived from a patient affected by severe EBS carrying the mutation KRT14 R125P. The gene discussed is METTL3; the disease is epidermolysis bullosa simplex.