Conversely, individuals in the highest GDF‐15 tertile (T3) had higher adjusted HRs compared with those in the lowest tertile (T1), as follows: 1.61 (95% CI: 0.79–2.37) for CKD progression, 5.47 (95% CI: 1.59–18.80) for mortality and 2.37 (95% CI: 1.30–4.30) for composite outcome. This evidence concerns the gene GDF15 and chronic kidney disease.