The structural equation model showed that mental health indicators such as anxiety and positive emotions are potential mediators, and that proinflammatory cytokines such as interleukin‐6 (IL6) and tumor necrosis factor‐α (TNF‐α) may reduce subjective health‐related QOL by increasing anxiety and suppressing positive emotions, without being particularly related to physical disease severity. The gene discussed is TNF; the disease is Anxiety.