YUM70, a derivative of 8-hydroxyquinone identified in 2021 in a phenotypic screen for cytotoxicity from 40,000 drug-like compounds, inhibited pancreatic cancer growth with no apparent toxicity to normal tissues, and subsequently determined that it directly binds GRP78, inactivating its function and triggering ER-stress mediated apoptosis (102). This evidence concerns the gene HSPA5 and familial pancreatic carcinoma.