HSPA5 and acute myeloid leukemia: Jude Children’s Research Hospital, TN generated for the first time a peptide-based GRP78 CAR, showing that GRP78 was expressed on the cell surface of primary AML blasts but not hematopoietic progenitor cells (HPCs), and CAR-T cells directed to cs78 via Pep42 exhibited robust anti-AML activity without HPC toxicity (116).