Furthermore, a genome-wide CRISPR inhibition (CRISPRi) screen conducted in lung cancer cells demonstrated that knockout of CUL5, RBX2, or UBE2F (a specific E2 for CRL5 E3s) caused cells to become hypersensitive to a CDK9 inhibitor or MCL-1 inhibitor (Kabir et al., 2019). Here, MCL1 is linked to lung cancer.